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Sahu, Pratap Kumar
- Hepatoprotective Potentials of Butea monosperma Stem Bark Extract against Carbon Tetrachloride Induced Hepatotoxicity in Albino Rats
Abstract Views :245 |
PDF Views:2
Authors
Prashant Tiwari
1,
Kuldeep Kumar
2,
Rajnikant Panik
3,
Alok Pandey
4,
Ashish Pandey
4,
Pratap Kumar Sahu
5
Affiliations
1 Pinnacle Biomedical Research Institute Bhopal, Madhya Pradesh, IN
2 Smt. Vidyawati Collage of Pharmacy, Jhansi (Uttarpradesh), IN
3 Gover. Girls Polytechnic College, Raipur (Chhattisgarh), IN
4 Raipur Institute of Technology, Raipur (Chhattisgarh), IN
5 Siksha 'O' Anusandhan University, Bhubaneswar, Orissa, IN
1 Pinnacle Biomedical Research Institute Bhopal, Madhya Pradesh, IN
2 Smt. Vidyawati Collage of Pharmacy, Jhansi (Uttarpradesh), IN
3 Gover. Girls Polytechnic College, Raipur (Chhattisgarh), IN
4 Raipur Institute of Technology, Raipur (Chhattisgarh), IN
5 Siksha 'O' Anusandhan University, Bhubaneswar, Orissa, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 5 (2011), Pagination: 281-284Abstract
Carbon tetrachloride (CCl4) pharmacological tool to produce liver damage in rats. Silymarin (100 mg/kg) and extract of Butea monosperma (shown to be hepatoprotective substances) prevented the CCl4 induced toxicity. Hydroalcholic extract of the stem bark of Butea Monosperma was evaluated for its hepatoprotective. This in vitro efficacy was reinforced by a significant dose dependent hepatoprotection (at 100 mg/kg and 200mg/kg dose) by decreasing the activity of serum enzymes, bilirubin, and lipid peroxidation while it significantly increased the reduced Glutathione levels of tissue in a dose dependant manner. The Hepatoprotective activities of the extract are being comparable to standards Silymarin. The results obtained in the present study indicate that stem bark extract of Butea Monosperma is a potential source of natural hepatoprotective. The hepatoprotective property may be attributed to the antioxidant potential and the phytochemical constituents of the plant. The present study justifies the claim of the native practitioner that the decoction of the plant is useful in treating jaundice and find out the clinical efficacy of the Butea Monosperma.Keywords
Carbon Tetrachloride, Butea Monosperma, Silymarin, Alanine Amino Transferase, Glutathione, Serum Glutamate Oxaloacetate Transaminase, Serum Glutamate Pyruvate Transaminase and Hepatoprotection.References
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- Physical Rheological and Cell Viability Study of Some Selected Plant Polysaccharides
Abstract Views :142 |
PDF Views:3
Authors
Affiliations
1 Maharana Pratap College of Pharmacy, Kanpur, 209217, IN
2 Meerut Institute of Engineering and Technology, NH- 58, Baghpat Crossing, Partapur Bypass Road, Meerut, 250005,, IN
3 School of Pharmaceutical Sciences, Siksha 'O' Anusandhan University, Bhubaneswar, 751030, IN
4 Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow, 226025, IN
1 Maharana Pratap College of Pharmacy, Kanpur, 209217, IN
2 Meerut Institute of Engineering and Technology, NH- 58, Baghpat Crossing, Partapur Bypass Road, Meerut, 250005,, IN
3 School of Pharmaceutical Sciences, Siksha 'O' Anusandhan University, Bhubaneswar, 751030, IN
4 Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow, 226025, IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 1 (2017), Pagination: 227-232Abstract
In the present work dry polysaccharides were extracted from two traditional plants, fenugreek (Trigonella Foenum graecum) and tamarind (Tamarindus indica). Both extracted polysaccharide were subjected for several parameter to find out their suitability used as pharmaceutical excipients. Polysaccharides were evaluated for their physicochemical parameters which revealed an acceptable range of micrometric properties. Mean value of total percentage glucose concentration in fenugreek and tamarind was calculated 23.5±4.72 and 31.9±6.32 respectively. Molecular weight of fenugreek and tamarind was estimated by refractive index method which found to be 2.03x10-6 and 1.79 x 106 kg/kg mol respectively. Rheological study indicates that aqueous solution of both polysaccharide possessed non-newtonian pseudoplastic flow behavior. Finally, cell viability assay confirm that both polysaccharide may be considered as safe excipients during drug delivery. The study confirmed that both plat polysaccharides (Trigonella foenum graecum) and (Tamarindus indica) can be considered as effective pharmaceutical excipients for the preparation of novel drug delivery systems.Keywords
Trigonella foenum graecum, Tamarindus indiaca, Rheology, Brookfield Rheometer, Pseudoplastic.- Nigella sativa:Phytochemistry, Pharmacology and its Therapeutic Potential
Abstract Views :476 |
PDF Views:1
Authors
Affiliations
1 Department of Pharmacology, School of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to be University), Bhubaneswar-751029, IN
1 Department of Pharmacology, School of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to be University), Bhubaneswar-751029, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 7 (2019), Pagination: 3111-3116Abstract
Nigella sativa belonging to family ranunculaceae. This plant is an extensively used as medicinal plant in India as well as all over the world. Nigella sativa (N. sativa) is well known plant of traditional systems of medicine such as Ayurveda, Siddha and Unani. It is also known as nutmeg flower, black seed, black cumin, black caraway, fennel flower, roman coriander, and kalonji. Alkaloids, phenols, flavonoids, glycosides, terpenoids and steroids are the important phyto constituents of N. sativa. The active constituents of N. sativa are thymohydroquinone, p-cymene, dithymoquinone, thymoquinone, carvacrol, sesquiterpene longifolene. N. sativa seed also contains pentacyclic triterpene, alpha-hederin, protein, carbohydrates, crude fibre, fat and saponin. N. sativa oil contains oleic acid, palmitic acid, linoleic acid. Aromatics contain α-thujene, thymol, α-pinene, thymoquinone, dihydrothymoquinone. N. sativa has been used as stimulant, emmenagogue, appetizer, pungent, anthelmintic, pungent, deodorant, carminative, purgative, expectorant, febrifuge, deodorant etc. N. sativa possess numerous pharmacological action such as antibacterial, antifungal, anticancer, hepatoprotective, antioxidant, antiinflammatory, analgesic, immunomodulatory, antidiabetic, dyslipidemia, antiepileptic, gastroprotective, antioxytocic, anti-fertility, respiratory, dermatological, nephroprotective, antiviral, testicular-protective, antidepressant and anticonvulsant activity. So considering the medicinal value and its therapeutic potential this review article would spotlight on phytochemistry, chemical composition and pharmacological activity of N. sativa.Keywords
Nigella sativa, Phytochemistry, Black Seed, Nutmeg Flower, Pharmacological Activity.References
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